ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic hernia

ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic hernia

Abstract Background Characterized by abnormal lung growth or maturation, congenital diaphragmatic hernia (CDH) affects 1:3000 live births. Cellular studies report proximal (SOX2+) and distal (SOX9+) progenitor cells as key modulators of branching morphogenesis and epithelial differentiation, whereas...

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Bibliographic Details
Main Authors: Ana N. Gonçalves, Jorge Correia-Pinto, Cristina Nogueira-Silva
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Respiratory Research
Subjects:
Branching
CDH
Epithelial progenitors
ROBO
SOX
Online Access:http://link.springer.com/article/10.1186/s12931-020-01568-w

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http://link.springer.com/article/10.1186/s12931-020-01568-w

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