In Silico studies of novel Sildenafil self-emulsifying drug delivery system absorption improvement for pulmonary arterial hypertension

In Silico studies of novel Sildenafil self-emulsifying drug delivery system absorption improvement for pulmonary arterial hypertension

Abstract Sildenafil is a potent selective inhibitor of phosphosdiesterase-5 previously used in erectile dysfunction and subsequently approved in 2005 for pulmonary arterial hypertension treatment. Since oral administration of sildenafil shows pharmacokinetic problems with mean absolute bioavailabili...

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Main Authors: BARBÁRA A. ABRAHIM-VIEIRA, ALESSANDRA M.T. DE SOUZA, RITA C. BARROS, FLÁVIA A. DO CARMO, LETÍCIA C.L. DE ABREU, RONYSON S.S. MOREIRA, THIAGO S. HONÓRIO, CARLOS R. RODRIGUES, VALERIA P. DE SOUSA, LUCIO M. CABRAL
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2020-08-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
In Silico evaluation
PBPK modeling
self-emulsifying drug delivery systems
Sildenafil
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300910&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300910&tlng=en

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