Contribution of S100A4-expressing fibroblasts to anti-SSA/Ro-associated atrioventricular nodal calcification and soluble S100A4 as a biomarker of clinical severity

Contribution of S100A4-expressing fibroblasts to anti-SSA/Ro-associated atrioventricular nodal calcification and soluble S100A4 as a biomarker of clinical severity

BackgroundFibrosis and dystrophic calcification disrupting conduction tissue architecture are histopathological lesions characterizing cardiac manifestations of neonatal lupus (cardiac-NL) associated with maternal anti-SSA/Ro antibodies.ObjectivesIncreased appreciation of heterogeneity in fibroblast...

Full description

Bibliographic Details
Main Authors: Christina E. M. Firl, Marc Halushka, Nicola Fraser, Mala Masson, Bettina F. Cuneo, Amit Saxena, Robert Clancy, Jill Buyon
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
congenital heart block (CHB)
congenital heart block and neonatal lupus risk
cardiac fibroblast (CF)
macrophage-fibroblast co-cultures
fibrosis
cardiac-NL
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114808/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114808/full

Similar Items