Contribution of S100A4-expressing fibroblasts to anti-SSA/Ro-associated atrioventricular nodal calcification and soluble S100A4 as a biomarker of clinical severity

Contribution of S100A4-expressing fibroblasts to anti-SSA/Ro-associated atrioventricular nodal calcification and soluble S100A4 as a biomarker of clinical severity

BackgroundFibrosis and dystrophic calcification disrupting conduction tissue architecture are histopathological lesions characterizing cardiac manifestations of neonatal lupus (cardiac-NL) associated with maternal anti-SSA/Ro antibodies.ObjectivesIncreased appreciation of heterogeneity in fibroblast...

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Bibliographic Details
Main Authors:	Christina E. M. Firl, Marc Halushka, Nicola Fraser, Mala Masson, Bettina F. Cuneo, Amit Saxena, Robert Clancy, Jill Buyon
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Series:	Frontiers in Immunology
Subjects:	congenital heart block (CHB) congenital heart block and neonatal lupus risk cardiac fibroblast (CF) macrophage-fibroblast co-cultures fibrosis cardiac-NL
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114808/full

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