Insights into species-specific regulation of ANP32A on the mammalian-restricted influenza virus polymerase activity

Insights into species-specific regulation of ANP32A on the mammalian-restricted influenza virus polymerase activity

ABSTRACTThe ANP32A is responsible for mammalian-restricted influenza virus polymerase activity. However, the mechanism of ANP32A modulation of polymerase activity remains poorly understood. Here, we report that chicken ANP32A (chANP32A) -X1 and -X2 stimulated mammalian-restricted PB2 627E polymerase...

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Bibliographic Details
Main Authors: Zhenwei Bi, Hongliu Ye, Xingbo Wang, An Fang, Tianqi Yu, Liping Yan, Jiyong Zhou
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Emerging Microbes and Infections
Subjects:
ANP32A
influenza A virus
polymerase activity
mammalian adaption
viral RNA
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2019.1676625

Internet

https://www.tandfonline.com/doi/10.1080/22221751.2019.1676625

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