SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic Pathways

SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic Pathways

Transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) have been extensively used to investigate the pathogenesis and tissue tropism of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Neuroinvasion and the replication of...

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Bibliographic Details
Main Authors: Hussin A. Rothan, Pratima Kumari, Shannon Stone, Janhavi P. Natekar, Komal Arora, Tabassum T. Auroni, Mukesh Kumar
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pathogens
Subjects:
COVID-19
SARS-CoV-2
K18-hACE2 mice
neurons
neuropathogenesis
inflammation
Online Access:https://www.mdpi.com/2076-0817/11/2/257

Internet

https://www.mdpi.com/2076-0817/11/2/257

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