SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic Pathways

SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic Pathways

Transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) have been extensively used to investigate the pathogenesis and tissue tropism of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Neuroinvasion and the replication of...

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Bibliographic Details
Main Authors:	Hussin A. Rothan, Pratima Kumari, Shannon Stone, Janhavi P. Natekar, Komal Arora, Tabassum T. Auroni, Mukesh Kumar
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	Pathogens
Subjects:	COVID-19 SARS-CoV-2 K18-hACE2 mice neurons neuropathogenesis inflammation
Online Access:	https://www.mdpi.com/2076-0817/11/2/257

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