Metabolic modulation: Pneumocystis phosphoglucomutase is a target influencing host recognition

Herein, this manuscript explores the significance of the phosphoglucomutase (PGM) enzyme in Pneumocystis spp., focusing on its role in fungal surface mannoprotein formation. Through expression of the Pneumocystis murina Pmpgm2 in a Saccharomyces cerevisiae pgm2Δ strain, we demonstrate restoration of...

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Bibliographic Details
Main Authors: Theodore J. Kottom, Eva M. Carmona, Bernd Lepenies, Andrew H. Limper
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:The Cell Surface
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2468233024000057