Chemical Genetic Screen in <i>Drosophila</i> Germline Uncovers Small Molecule Drugs That Sensitize Stem Cells to Insult-Induced Apoptosis

Chemical Genetic Screen in <i>Drosophila</i> Germline Uncovers Small Molecule Drugs That Sensitize Stem Cells to Insult-Induced Apoptosis

Cancer stem cells, in contrast to their more differentiated daughter cells, can endure genotoxic insults, escape apoptosis, and cause tumor recurrence. Understanding how normal adult stem cells survive and go to quiescence may help identify druggable pathways that cancer stem cells have co-opted. In...

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Bibliographic Details
Main Authors: Julien Roy Ishibashi, Riya Keshri, Tommy Henry Taslim, Daniel Kennedy Brewer, Tung Ching Chan, Scott Lyons, Anika Marie McManamen, Ashley Chen, Debra Del Castillo, Hannele Ruohola-Baker
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
<i>Drosophila</i>
germline
stem cells
apoptosis
cancer
quiescence
Online Access:https://www.mdpi.com/2073-4409/10/10/2771

Internet

https://www.mdpi.com/2073-4409/10/10/2771

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