Synthesis, molecular docking, and cytotoxicity of quinazolinone and dihydroquinazolinone derivatives as cytotoxic agents

Synthesis, molecular docking, and cytotoxicity of quinazolinone and dihydroquinazolinone derivatives as cytotoxic agents

Abstract Background Cancer is the most cause of morbidity and mortality, and a major public health problem worldwide. In this context, two series of quinazolinone 5a–e and dihydroquinazolinone 10a–f compounds were designed, synthesized as cytotoxic agents. Methodology All derivatives (5a–e and 10a–f...

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Bibliographic Details
Main Authors: Fahimeh Taayoshi, Aida Iraji, Ali Moazzam, Meysam Soleimani, Mehdi Asadi, Keyvan Pedrood, Mosayeb Akbari, Hafezeh Salehabadi, Bagher Larijani, Neda Adibpour, Mohammad Mahdavi
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Chemistry
Subjects:
Quinazolinone
Dihydroquinazolinone Cytotoxicity
Docking
PARPs
Synthesis
Online Access:https://doi.org/10.1186/s13065-022-00825-x

Internet

https://doi.org/10.1186/s13065-022-00825-x

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