Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome

Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome

Abstract Background B vitamins such as folate (B9), B6, and B12 are key in one carbon metabolism, which generates methyl donors for DNA methylation. Several studies have linked differential methylation to self-reported intakes of folate and B12, but these estimates can be imprecise, while metabolomi...

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Main Authors: Ricardo Costeira, Laila Evangelista, Rory Wilson, Xinyu Yan, Fabian Hellbach, Lucy Sinke, Colette Christiansen, Sergio Villicaña, Olatz M. Masachs, Pei-Chien Tsai, Massimo Mangino, Cristina Menni, Sarah E. Berry, Marian Beekman, Diana van Heemst, P. Eline Slagboom, Bastiaan T. Heijmans, Karsten Suhre, Gabi Kastenmüller, Christian Gieger, Annette Peters, Kerrin S. Small, Jakob Linseisen, Melanie Waldenberger, Jordana T. Bell
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
Metabolomics
Biomarkers
B vitamins
Folate
Diet
Online Access:https://doi.org/10.1186/s13148-023-01578-7

Internet

https://doi.org/10.1186/s13148-023-01578-7

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