Effect of Targeted Cytokine Inhibition on Progression of Post-Traumatic Osteoarthritis Following Intra-Articular Fracture

Effect of Targeted Cytokine Inhibition on Progression of Post-Traumatic Osteoarthritis Following Intra-Articular Fracture

Intra-articular fractures (IAF) result in significant and prolonged inflammation, increasing the chances of developing post-traumatic osteoarthritis (PTOA). Interleukin-one beta (IL-1β) and Tumor Necrosis Factor-alpha (TNF-α) are key inflammatory factors shown to be involved in osteochondral degrada...

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Bibliographic Details
Main Authors: Michael S. Valerio, Jorge B. Edwards, Connor P. Dolan, Jessica M. Motherwell, Benjamin K. Potter, Christopher L. Dearth, Stephen M. Goldman
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
articular cartilage
intra-articular fractures
post-traumatic osteoarthritis
synovial fluid
interleukin 1 receptor antagonist
tumor necrosis factor inhibitors
Online Access:https://www.mdpi.com/1422-0067/24/17/13606

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https://www.mdpi.com/1422-0067/24/17/13606

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