CAR-T manufactured from frozen PBMC yield efficient function with prolonged in vitro production

CAR-T manufactured from frozen PBMC yield efficient function with prolonged in vitro production

Chimeric antigen receptor (CAR)-T cells are engineered to identify and eliminate cells expressing a target antigen. Current manufacturing protocols vary between commercial CAR-T cell products warranting an assessment of these methods to determine which approach optimally balances successful manufact...

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Bibliographic Details
Main Authors: Julieta Abraham-Miranda, Meghan Menges, Reginald Atkins, Mike Mattie, Justyna Kanska, Joel Turner, Melanie J. Hidalgo-Vargas, Frederick L. Locke
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor T-cell
CAR-T cell
PBMC cryopreservation
CAR-T cell in vitro expansion
CAR-T cell cytokines production
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1007042/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1007042/full

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