Toll-like receptor 4 decoy, TOY, attenuates gram-negative bacterial sepsis.

Toll-like receptor 4 decoy, TOY, attenuates gram-negative bacterial sepsis.

Lipopolysaccharide (LPS), the Gram-negative bacterial outer membrane glycolipid, induces sepsis through its interaction with myeloid differentiation protein-2 (MD-2) and Toll-like receptor 4 (TLR4). To block interaction between LPS/MD-2 complex and TLR4, we designed and generated soluble fusion prot...

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Bibliographic Details
Main Authors: Keehoon Jung, Jung-Eun Lee, Hak-Zoo Kim, Ho Min Kim, Beom Seok Park, Seong-Ik Hwang, Jie-Oh Lee, Sun Chang Kim, Gou Young Koh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2754608?pdf=render

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http://europepmc.org/articles/PMC2754608?pdf=render

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