Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition

Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition

Abstract Background During metastasis, cancer cells undergo epithelial-mesenchymal transition (EMT) in response to transforming growth factor-β (TGF-β), which is abundant in the tumor microenvironment, and acquire invasive and metastatic potentials. Metastasis to distant organs requires intravascula...

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Bibliographic Details
Main Authors: Miho Kobayashi, Kashio Fujiwara, Kazuki Takahashi, Yusuke Yoshioka, Takahiro Ochiya, Katarzyna A. Podyma-Inoue, Tetsuro Watabe
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Inflammation and Regeneration
Subjects:
Extracellular vesicles
Epithelial-mesenchymal transition
Endothelial-mesenchymal transition
Transforming growth factor-β
Endothelial barrier
Pre-metastatic niches
Online Access:https://doi.org/10.1186/s41232-022-00225-7

Internet

https://doi.org/10.1186/s41232-022-00225-7

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