A TetR family regulator of an RND efflux system that directs artemisinin resistance in Vibrio cholerae

A TetR family regulator of an RND efflux system that directs artemisinin resistance in Vibrio cholerae

ABSTRACTArtemisinin (ARS) displayed bactericidal activity against Vibrio cholerae. To assess the mechanistic details of its antibacterial action, we have isolated V. cholerae mutants with enhanced ARS resistance and identified a gene (VCA0767) whose loss-of-function resulted in the ARS resistance ph...

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Bibliographic Details
Main Authors: In-Young Chung, Shin-Yae Choi, Hee-Won Bae, You-Hee Cho
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mSystems
Subjects:
artemisinin
antimalarial
antibacterial
RND efflux
VexAB
TolC
Online Access:https://journals.asm.org/doi/10.1128/msystems.00851-23

Internet

https://journals.asm.org/doi/10.1128/msystems.00851-23

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