Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer’s Disease-like Pathology

Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer’s Disease-like Pathology

Amyloid beta (Aβ) peptides impair multiple cellular pathways and play a causative role in Alzheimer’s disease (AD) pathology, but how the brain proteome is remodeled by this process is unknown. To identify protein networks associated with AD-like pathology, we performed global quantitative proteomic...

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Bibliographic Details
Main Authors: Jeffrey N. Savas, Yi-Zhi Wang, Laura A. DeNardo, Salvador Martinez-Bartolome, Daniel B. McClatchy, Timothy J. Hark, Natalie F. Shanks, Kira A. Cozzolino, Mathieu Lavallée-Adam, Samuel N. Smukowski, Sung Kyu Park, Jeffery W. Kelly, Edward H. Koo, Terunaga Nakagawa, Eliezer Masliah, Anirvan Ghosh, John R. Yates, III
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Cell Reports
Subjects:
AD
proteomics
mass spectrometry
synapses
proteostasis
WGCNA
amyloid beta
ApoE
AMPAR
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717316297

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http://www.sciencedirect.com/science/article/pii/S2211124717316297

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