Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats

Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats

Abstract Background The brain extracellular fluid (ECF), composed of secreted neurotransmitters, metabolites, peptides, and proteins, may reflect brain processes. Analysis of brain ECF may provide new potential markers for synaptic activity or brain damage and reveal additional information on pathol...

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Bibliographic Details
Main Authors: Vanda Tukacs, Dániel Mittli, Éva Hunyadi-Gulyás, Zsuzsanna Darula, Gábor Juhász, József Kardos, Katalin Adrienna Kékesi
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Fluids and Barriers of the CNS
Subjects:
Microdialysis
Peptidomics
Seizure
4-Aminopyridine
Online Access:https://doi.org/10.1186/s12987-024-00508-w

Internet

https://doi.org/10.1186/s12987-024-00508-w

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