Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits

Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits

Abstract Cerebellar dysfunction is commonly observed following traumatic brain injury (TBI). While direct impact to the cerebellum by TBI is rare, cerebellar pathology may be caused by indirect injury via cortico-cerebellar pathways. To address the hypothesis that degeneration of Purkinje cells (PCs...

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Bibliographic Details
Main Authors: Ilknur Özen, Hongcheng Mai, Alessandro De Maio, Karsten Ruscher, Georgios Michalettos, Fredrik Clausen, Michael Gottschalk, Saema Ansar, Sertan Arkan, Ali Erturk, Niklas Marklund
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Acta Neuropathologica Communications
Subjects:
Traumatic brain injury (TBI)
Demyelination
Axonal injury
Cerebellum
Purkinje cell
Central (midline) fluid percussion
Online Access:https://doi.org/10.1186/s40478-022-01435-3

Internet

https://doi.org/10.1186/s40478-022-01435-3

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