Expression and Purification of Hybrid LL-37Tα1 Peptide in Pichia pastoris and Evaluation of Its Immunomodulatory and Anti-inflammatory Activities by LPS Neutralization

Expression and Purification of Hybrid LL-37Tα1 Peptide in Pichia pastoris and Evaluation of Its Immunomodulatory and Anti-inflammatory Activities by LPS Neutralization

This study pertains to the new approach for the development of hybrid peptide LL-37Tα1 and its biomedical applications. A linear cationic hybrid peptide, LL-37Tα1 was derived from two parental peptides (LL-37 and Tα1) recognized as potent anti-endotoxin without any hemolytic or cytotoxic activity. W...

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Bibliographic Details
Main Authors: Baseer Ahmad, Quratulain Hanif, Wei Xubiao, Zhang Lulu, Muhammad Shahid, Si Dayong, Zhang Rijun
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
hybrid peptides
yeast expression
LPS neutralization
immunomodulatory
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01365/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01365/full

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