Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets

Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets

Ubiquitin–proteasome system (UPS) is a primary signaling pathway for regulation of intracellular protein levels. E3 ubiquitin ligases, substrate-specific members of the UPS, represent highly attractive protein targets for drug discovery. The importance of E3 ligases as prospective targets for small...

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Bibliographic Details
Main Authors: Emil Bulatov, Almaz Zagidullin, Aygul Valiullina, Regina Sayarova, Albert Rizvanov
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
ubiquitin–proteasome system
RING-type E3 ligases
MDM family
Cullin family
small molecules
induced protein degradation
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00450/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00450/full

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