Structure-activity relationships of thiadiazole agonists of the human secretin receptor

Structure-activity relationships of thiadiazole agonists of the human secretin receptor

Agonists of the secretin receptor have potential applications for diseases of the cardiovascular, gastrointestinal, and metabolic systems, yet no clinically-active non-peptidyl agonists of this receptor have yet been developed. In the current work, we have identified a new small molecule lead compou...

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Bibliographic Details
Main Authors: Robert Ardecky, Daniela G. Dengler, Kaleeckal G. Harikumar, Mathew M. Abelman, Jiwen Zou, Bryan A. Kramer, Santhi Reddy Ganji, Steve Olson, Alina Ly, Nikhil Puvvula, Chen-Ting Ma, Raghuveer Ramachandra, Eduard A. Sergienko, Laurence J. Miller
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:SLAS Discovery
Subjects:
Secretin receptor
G protein-coupled receptor
Structure-activity relationships
Small molecule agonist
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555224000388

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http://www.sciencedirect.com/science/article/pii/S2472555224000388

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