Targeting Lysosomes to Reverse Hydroquinone-Induced Autophagy Defects and Oxidative Damage in Human Retinal Pigment Epithelial Cells

Targeting Lysosomes to Reverse Hydroquinone-Induced Autophagy Defects and Oxidative Damage in Human Retinal Pigment Epithelial Cells

In age-related macular degeneration (AMD), hydroquinone (HQ)-induced oxidative damage in retinal pigment epithelium (RPE) is believed to be an early event contributing to dysregulation of inflammatory cytokines and vascular endothelial growth factor (VEGF) homeostasis. However, the roles of antioxid...

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Bibliographic Details
Main Authors: Samuel Abokyi, Sze-Wan Shan, Christie Hang-I Lam, Kirk Patrick Catral, Feng Pan, Henry Ho-Lung Chan, Chi-Ho To, Dennis Yan-Yin Tse
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
age-related macular degeneration
hydroquinone
oxidative stress
autophagy
ubiquitin-proteasome system (UPS)
lysosomal alkalization
Online Access:https://www.mdpi.com/1422-0067/22/16/9042

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https://www.mdpi.com/1422-0067/22/16/9042

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