Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitriles from enones

Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitriles from enones

The cyclocondensation of enones with aminoacetonitrile furnishes 3,4-dihydro-2H-pyrrole-2-carbonitriles which can be readily converted to 2,4-disubstituted pyrroles by microwave-induced dehydrocyanation. Alternatively, oxidation of the intermediates produces 3,5-disubstituted pyrrole-2-carbonitriles...

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Bibliographic Details
Main Authors: Murat Kucukdisli, Dorota Ferenc, Marcel Heinz, Christine Wiebe, Till Opatz
Format: Article
Language:English
Published: Beilstein-Institut 2014-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
α-aminonitriles
cyclization
heterocycles
microwave-assisted synthesis
pyrroles
Online Access:https://doi.org/10.3762/bjoc.10.44

Internet

https://doi.org/10.3762/bjoc.10.44

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