The NMR studies of CMP inhibition of polysialylation

The NMR studies of CMP inhibition of polysialylation

The overexpression of polysialic acid (polySia) on neural cell adhesion molecules (NCAM) promotes hypersialylation, and thus benefits cancer cell migration and invasion. It has been proposed that the binding between the polysialyltransferase domain (PSTD) and CMP-Sia needs to be inhibited in order t...

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Bibliographic Details
Main Authors: Bo Lu, Si-Ming Liao, Xue-Hui Liu, Shi-Jie Liang, Jun Huang, Mei Lin, Li Meng, Qing-Yan Wang, Ri-Bo Huang, Guo-Ping Zhou
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Metastatic spread
polysialic acid
polysialyltransferase
polysialyltransferase domain
chemical shift perturbation
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2248411

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https://www.tandfonline.com/doi/10.1080/14756366.2023.2248411

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