Histological and biochemical evaluation of transforming growth factor-β activation and its clinical significance in patients with chronic liver disease

Histological and biochemical evaluation of transforming growth factor-β activation and its clinical significance in patients with chronic liver disease

Transforming growth factor-β (TGF-β) is a key driver for liver fibrogenesis. TGF-β must be activated in order to function. Plasma kallikrein (PLK) is a TGF-β activator that cleaves the latency-associated protein (LAP) between arginine58 and lysine59 residues and releases active TGF-β from the latent...

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Bibliographic Details
Main Authors: Hiroshi Yokoyama, Takahiro Masaki, Ikuyo Inoue, Mariko Nakamura, Yoshihiro Mezaki, Chisato Saeki, Tsunekazu Oikawa, Masayuki Saruta, Hiroyuki Takahashi, Masahiro Ikegami, Hiroshi Hano, Kenichi Ikejima, Soichi Kojima, Tomokazu Matsuura
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Heliyon
Subjects:
Internal medicine
Pathology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018355774

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http://www.sciencedirect.com/science/article/pii/S2405844018355774

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