Toward a pan-SARS-CoV-2 vaccine targeting conserved epitopes on spike and non-spike proteins for potent, broad and durable immune responses.

Toward a pan-SARS-CoV-2 vaccine targeting conserved epitopes on spike and non-spike proteins for potent, broad and durable immune responses.

<h4>Background</h4>The SARS-CoV-2 non-Spike (S) structural protein targets on nucleocapsid (N), membrane (M) and envelope (E), critical in the host cell interferon response and memory T-cell immunity, are grossly overlooked in COVID vaccine development. The current Spike-only vaccines be...

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Bibliographic Details
Main Authors: Chang Yi Wang, Wen-Jiun Peng, Be-Sheng Kuo, Yu-Hsin Ho, Min-Sheng Wang, Ya-Ting Yang, Po-Yen Chang, Yea-Huei Shen, Kao-Pin Hwang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010870

Internet

https://doi.org/10.1371/journal.ppat.1010870

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