Extent of arterial calcification by conventional vitamin K antagonist treatment.
<h4>Background and aims</h4>Vitamin K antagonists (VKA) remain the most frequently prescribed oral anticoagulants worldwide despite the introduction of non-vitamin K antagonist oral anticoagulants (NOAC). VKA interfere with the regeneration of Vitamin K1 and K2, essential to the activati...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0241450 |
| _version_ | 1830453437270065152 |
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| author | Selma Hasific Kristian Altern Øvrehus Oke Gerke Jesper Hallas Martin Busk Jess Lambrechtsen Grazina Urbonaviciene Niels Peter Rønnow Sand Jens Steen Nielsen Louise Diederichsen Kenneth Bruun Pedersen Rasmus Carter-Storch Nivethitha Ilangkovan Hans Mickley Lars Melholt Rasmussen Jes Sandal Lindholt Axel Diederichsen |
| author_facet | Selma Hasific Kristian Altern Øvrehus Oke Gerke Jesper Hallas Martin Busk Jess Lambrechtsen Grazina Urbonaviciene Niels Peter Rønnow Sand Jens Steen Nielsen Louise Diederichsen Kenneth Bruun Pedersen Rasmus Carter-Storch Nivethitha Ilangkovan Hans Mickley Lars Melholt Rasmussen Jes Sandal Lindholt Axel Diederichsen |
| author_sort | Selma Hasific |
| collection | DOAJ |
| description | <h4>Background and aims</h4>Vitamin K antagonists (VKA) remain the most frequently prescribed oral anticoagulants worldwide despite the introduction of non-vitamin K antagonist oral anticoagulants (NOAC). VKA interfere with the regeneration of Vitamin K1 and K2, essential to the activation of coagulation factors and activation of matrix-Gla protein, a strong inhibitor of arterial calcifications. This study aimed to clarify whether VKA treatment was associated with the extent of coronary artery calcification (CAC) in a population with no prior cardiovascular disease (CVD).<h4>Methods</h4>We collected data on cardiovascular risk factors and CAC scores from cardiac CT scans performed as part of clinical examinations (n = 9,672) or research studies (n = 14,166) in the period 2007-2017. Data on use of anticoagulation were obtained from the Danish National Health Service Prescription Database. The association between duration of anticoagulation and categorized CAC score (0, 1-99, 100-399, ≥400) was investigated by ordered logistic regression adjusting for covariates.<h4>Results</h4>The final study population consisted of 17,254 participants with no prior CVD, of whom 1,748 and 1,144 had been treated with VKA or NOAC, respectively. A longer duration of VKA treatment was associated with higher CAC categories. For each year of VKA treatment, the odds of being in a higher CAC category increased (odds ratio (OR) = 1.032, 95%CI 1.009-1.057). In contrast, NOAC treatment duration was not associated with CAC category (OR = 1.002, 95%CI 0.935-1.074). There was no significant interaction between VKA treatment duration and age on CAC category.<h4>Conclusions</h4>Adjusted for cardiovascular risk factors, VKA treatment-contrary to NOAC-was associated to higher CAC category. |
| first_indexed | 2024-12-21T09:07:02Z |
| format | Article |
| id | doaj.art-3ee7a0fa6914435aa2fba2b56523c1a0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T09:07:02Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3ee7a0fa6914435aa2fba2b56523c1a02022-12-21T19:09:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011510e024145010.1371/journal.pone.0241450Extent of arterial calcification by conventional vitamin K antagonist treatment.Selma HasificKristian Altern ØvrehusOke GerkeJesper HallasMartin BuskJess LambrechtsenGrazina UrbonavicieneNiels Peter Rønnow SandJens Steen NielsenLouise DiederichsenKenneth Bruun PedersenRasmus Carter-StorchNivethitha IlangkovanHans MickleyLars Melholt RasmussenJes Sandal LindholtAxel Diederichsen<h4>Background and aims</h4>Vitamin K antagonists (VKA) remain the most frequently prescribed oral anticoagulants worldwide despite the introduction of non-vitamin K antagonist oral anticoagulants (NOAC). VKA interfere with the regeneration of Vitamin K1 and K2, essential to the activation of coagulation factors and activation of matrix-Gla protein, a strong inhibitor of arterial calcifications. This study aimed to clarify whether VKA treatment was associated with the extent of coronary artery calcification (CAC) in a population with no prior cardiovascular disease (CVD).<h4>Methods</h4>We collected data on cardiovascular risk factors and CAC scores from cardiac CT scans performed as part of clinical examinations (n = 9,672) or research studies (n = 14,166) in the period 2007-2017. Data on use of anticoagulation were obtained from the Danish National Health Service Prescription Database. The association between duration of anticoagulation and categorized CAC score (0, 1-99, 100-399, ≥400) was investigated by ordered logistic regression adjusting for covariates.<h4>Results</h4>The final study population consisted of 17,254 participants with no prior CVD, of whom 1,748 and 1,144 had been treated with VKA or NOAC, respectively. A longer duration of VKA treatment was associated with higher CAC categories. For each year of VKA treatment, the odds of being in a higher CAC category increased (odds ratio (OR) = 1.032, 95%CI 1.009-1.057). In contrast, NOAC treatment duration was not associated with CAC category (OR = 1.002, 95%CI 0.935-1.074). There was no significant interaction between VKA treatment duration and age on CAC category.<h4>Conclusions</h4>Adjusted for cardiovascular risk factors, VKA treatment-contrary to NOAC-was associated to higher CAC category.https://doi.org/10.1371/journal.pone.0241450 |
| spellingShingle | Selma Hasific Kristian Altern Øvrehus Oke Gerke Jesper Hallas Martin Busk Jess Lambrechtsen Grazina Urbonaviciene Niels Peter Rønnow Sand Jens Steen Nielsen Louise Diederichsen Kenneth Bruun Pedersen Rasmus Carter-Storch Nivethitha Ilangkovan Hans Mickley Lars Melholt Rasmussen Jes Sandal Lindholt Axel Diederichsen Extent of arterial calcification by conventional vitamin K antagonist treatment. PLoS ONE |
| title | Extent of arterial calcification by conventional vitamin K antagonist treatment. |
| title_full | Extent of arterial calcification by conventional vitamin K antagonist treatment. |
| title_fullStr | Extent of arterial calcification by conventional vitamin K antagonist treatment. |
| title_full_unstemmed | Extent of arterial calcification by conventional vitamin K antagonist treatment. |
| title_short | Extent of arterial calcification by conventional vitamin K antagonist treatment. |
| title_sort | extent of arterial calcification by conventional vitamin k antagonist treatment |
| url | https://doi.org/10.1371/journal.pone.0241450 |
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