Double‐strand DNA break repair: molecular mechanisms and therapeutic targets

Double‐strand DNA break repair: molecular mechanisms and therapeutic targets

Abstract Double‐strand break (DSB), a significant DNA damage brought on by ionizing radiation, acts as an initiating signal in tumor radiotherapy, causing cancer cells death. The two primary pathways for DNA DSB repair in mammalian cells are nonhomologous end joining (NHEJ) and homologous recombinat...

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Bibliographic Details
Main Authors: Jinpeng Tan, Xingyao Sun, Hongling Zhao, Hua Guan, Shanshan Gao, Ping‐Kun Zhou
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:MedComm
Subjects:
DSB repair
HR
Ku70/80 heterodimer/DNA–PKcs (DNA–PK)
MRN complex
NHEJ
Therapeutic targets
Online Access:https://doi.org/10.1002/mco2.388

Internet

https://doi.org/10.1002/mco2.388

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