Double‐strand DNA break repair: molecular mechanisms and therapeutic targets
Abstract Double‐strand break (DSB), a significant DNA damage brought on by ionizing radiation, acts as an initiating signal in tumor radiotherapy, causing cancer cells death. The two primary pathways for DNA DSB repair in mammalian cells are nonhomologous end joining (NHEJ) and homologous recombinat...
Main Authors: | Jinpeng Tan, Xingyao Sun, Hongling Zhao, Hua Guan, Shanshan Gao, Ping‐Kun Zhou |
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Format: | Article |
Language: | English |
Published: |
Wiley
2023-10-01
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Series: | MedComm |
Subjects: | |
Online Access: | https://doi.org/10.1002/mco2.388 |
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