Whole Genome Analysis of Ovarian Granulosa Cell Tumors Reveals Tumor Heterogeneity and a High-Grade TP53-Specific Subgroup

Whole Genome Analysis of Ovarian Granulosa Cell Tumors Reveals Tumor Heterogeneity and a High-Grade TP53-Specific Subgroup

Adult granulosa cell tumors (AGCTs) harbor a somatic <i>FOXL2</i> c.402C>G mutation in ~95% of cases and are mainly surgically removed due to limited systemic treatment effect. In this study, potentially targetable genomic alterations in AGCTs were investigated by whole genome sequenc...

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Bibliographic Details
Main Authors: Joline Roze, Glen Monroe, Joachim Kutzera, Jolijn Groeneweg, Ellen Stelloo, Sterre Paijens, Hans Nijman, Hannah van Meurs, Luc van Lonkhuijzen, Jurgen Piek, Christianne Lok, Geertruida Jonges, Petronella Witteveen, René Verheijen, Gijs van Haaften, Ronald Zweemer
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
whole genome sequencing
granulosa cell tumors
ovarian cancer
FOXL2
tumor heterogeneity
Online Access:https://www.mdpi.com/2072-6694/12/5/1308

Internet

https://www.mdpi.com/2072-6694/12/5/1308

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