Urinary Measurement of Epigenetic DNA Modifications and 8-oxodG as Possible Noninvasive Markers of Colon Cancer Evolution

Urinary Measurement of Epigenetic DNA Modifications and 8-oxodG as Possible Noninvasive Markers of Colon Cancer Evolution

The active DNA demethylation mechanism involves 5-methylcytosine (5-mCyt) enzymatic oxidation with the subsequent formation of 5-hydroxymethylcytosine (5-hmCyt), which can be further oxidized to 5-formylcytosine (5-fCyt) and 5-carboxylcytosine (5-caCyt). The products of active DNA demethylation are...

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Bibliographic Details
Main Authors: Aleksandra Skalska-Bugala, Agnieszka Siomek-Gorecka, Zbigniew Banaszkiewicz, Ryszard Olinski, Rafal Rozalski
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
DNA demethylation
colon cancer
inflammatory bowel disease
adenoma
DNA epigenetic modification
2D-UPLC-MS/MS
Online Access:https://www.mdpi.com/1422-0067/23/22/13826

Internet

https://www.mdpi.com/1422-0067/23/22/13826

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