Pharmacological activation of GPX4 ameliorates doxorubicin-induced cardiomyopathy

Pharmacological activation of GPX4 ameliorates doxorubicin-induced cardiomyopathy

Due to the cardiotoxicity of doxorubicin (DOX), its clinical application is limited. Lipid peroxidation caused by excessive ferrous iron is believed to be a key molecular mechanism of DOX-induced cardiomyopathy (DIC). Dexrazoxane (DXZ), an iron chelator, is the only drug approved by the FDA for redu...

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Bibliographic Details
Main Authors: Chuying Huang, Yishan Guo, Tuo Li, Guogen Sun, Jinru Yang, Yuqi Wang, Ying Xiang, Li Wang, Min Jin, Jiao Li, Yong Zhou, Bing Han, Rui Huang, Jiao Qiu, Yong Tan, Jiaxing Hu, Yumiao Wei, Bo Wu, Yong Mao, Lingshan Lei, Xiusheng Song, Shuijie Li, Yongsheng Wang, Tao Zhang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Redox Biology
Subjects:
DOX
Cardiotoxicity
GPX4
scRNA-seq
Selenium
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723004251

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http://www.sciencedirect.com/science/article/pii/S2213231723004251

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