Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy

Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy

Abstract Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiac disease in humans and cats and lacks efficacious pharmacologic interventions in the preclinical phase of disease. LV outflow tract obstruction (LVOTO) is commonly observed in HCM-affected patients and is a primary dri...

Full description

Bibliographic Details
Main Authors: Ashley N. Sharpe, Maureen S. Oldach, Victor N. Rivas, Joanna L. Kaplan, Ashley L. Walker, Samantha L. Kovacs, Darren T. Hwee, Peadar Cremin, Bradley P. Morgan, Fady I. Malik, Samantha P. Harris, Joshua A. Stern
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-26630-z

Internet

https://doi.org/10.1038/s41598-022-26630-z

Similar Items