Dexmedetomidine Promotes Lipopolysaccharide-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through α<sub>2A</sub> Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice

Dexmedetomidine Promotes Lipopolysaccharide-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through α<sub>2A</sub> Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice

Dexmedetomidine (DEX), a selective α<sub>2</sub> adrenergic receptor (AR) agonist, is commonly used as a sedative drug during critical illness. In the present study, we explored a novel accelerative effect of DEX on cardiac fibroblast (CF) differentiation mediated by LPS and clarified it...

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Bibliographic Details
Main Authors: Jia Liao, Kaiying Li, Xingyu Su, Yihua Chen, Yingwei Wang, Xiangxu Tang, Yun Xing, Yaqian Xu, Xiaomeng Dai, Jiashuo Teng, Hongmei Li, Huadong Wang, Xiuxiu Lv, Yiyang Wang
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
dexmedetomidine
cardiac fibroblast
differentiation
lipopolysaccharide
α<sub>2</sub> adrenergic receptor
Online Access:https://www.mdpi.com/1422-0067/22/23/12749

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https://www.mdpi.com/1422-0067/22/23/12749

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