Combined Dopamine and Grape Seed Extract-Loaded Solid Lipid Nanoparticles: Nasal Mucosa Permeation, and Uptake by Olfactory Ensheathing Cells and Neuronal SH-SY5Y Cells

Combined Dopamine and Grape Seed Extract-Loaded Solid Lipid Nanoparticles: Nasal Mucosa Permeation, and Uptake by Olfactory Ensheathing Cells and Neuronal SH-SY5Y Cells

We have already formulated solid lipid nanoparticles (SLNs) in which the combination of the neurotransmitter dopamine (DA) and the antioxidant grape-seed-derived proanthocyanidins (grape seed extract, GSE) was supposed to be favorable for Parkinson’s disease (PD) treatment. In fact, GSE supply would...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Adriana Trapani, Stefano Castellani, Lorenzo Guerra, Elvira De Giglio, Giuseppe Fracchiolla, Filomena Corbo, Nicola Cioffi, Giuseppe Passantino, Maria Luana Poeta, Pasqualina Montemurro, Rosanna Mallamaci, Rosa Angela Cardone, Massimo Conese
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: MDPI AG 2023-03-01
Cyfres:Pharmaceutics
Pynciau:
colloids
dopamine
grape seed extract
intranasal administration
olfactory ensheathing cells
SH-SY5Y cells
Mynediad Ar-lein:https://www.mdpi.com/1999-4923/15/3/881

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https://www.mdpi.com/1999-4923/15/3/881

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