Identification of a claudin-low subtype in clear cell renal cell carcinoma with implications for the evaluation of clinical outcomes and treatment efficacy

Identification of a claudin-low subtype in clear cell renal cell carcinoma with implications for the evaluation of clinical outcomes and treatment efficacy

BackgroundIn bladder and breast cancer, the claudin-low subtype is widely identified, revealing a distinct tumor microenvironment (TME) and immunological feature. Although we have previously identified individual claudin members as prognostic biomarkers in clear cell renal cell carcinoma (ccRCC), th...

Full description

Bibliographic Details
Main Authors:	Cuijian Zhang, Yifan Li, Jinqin Qian, Zhenpeng Zhu, Cong Huang, Zhisong He, Liqun Zhou, Yanqing Gong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Series:	Frontiers in Immunology
Subjects:	clear cell renal cell carcinoma (ccRCC) claudin tumor microenvironment immunity prognosis immune checkpoint inhibitor (ICI)
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1020729/full

Similar Items

The Ion Channel-Related Gene Signatures Correlated With Diagnosis, Prognosis, and Individualized Treatment in Patients With Clear Cell Renal Cell Carcinoma
by: Zhenpeng Zhu, et al.
Published: (2022-06-01)

Construction and validation of a ferroptosis-related long noncoding RNA signature in clear cell renal cell carcinoma
by: Zhenpeng Zhu, et al.
Published: (2022-09-01)

Upregulation of BMP1 through ncRNAs correlates with adverse outcomes and immune infiltration in clear cell renal cell carcinoma
by: Mancheng Gong, et al.
Published: (2023-10-01)

Multi-Omics Analysis of the Prognosis and Biological Function for TRPV Channel Family in Clear Cell Renal Cell Carcinoma
by: Yuxiong Jiang, et al.
Published: (2022-04-01)

Pyroptosis-Related lncRNA Prognostic Model for Renal Cancer Contributes to Immunodiagnosis and Immunotherapy
by: Xuan Zhou, et al.
Published: (2022-07-01)

TRAF2 promotes M2-polarized tumor-associated macrophage infiltration, angiogenesis and cancer progression by inhibiting autophagy in clear cell renal cell carcinoma
by: Yawei Xu, et al.
Published: (2023-07-01)

Metabolic reprogramming of clear cell renal cell carcinoma
by: Haiyan Zhu, et al.
Published: (2023-06-01)

PLAC8 is an innovative biomarker for immunotherapy participating in remodeling the immune microenvironment of renal clear cell carcinoma
by: Xu Sun, et al.
Published: (2023-10-01)

Increased expression of the RNA-binding protein Musashi-2 is associated with immune infiltration and predicts better outcomes in ccRCC patients
by: Hui Li, et al.
Published: (2022-10-01)

Novel Prognosis and Therapeutic Response Model of Immune-Related lncRNA Pairs in Clear Cell Renal Cell Carcinoma
by: Gang Wang, et al.
Published: (2022-07-01)

KL is a favorable prognostic factor related immune for clear cell renal cell carcinoma
by: Ke-Hao Pan, et al.
Published: (2023-09-01)

Autophagy-related gene LAPTM4B promotes the progression of renal clear cell carcinoma and is associated with immunity
by: He Wang, et al.
Published: (2023-03-01)

A New Prognostic Risk Signature of Eight Ferroptosis-Related Genes in the Clear Cell Renal Cell Carcinoma
by: Ji Chen, et al.
Published: (2021-06-01)

Identification of an immune subtype-related prognostic signature of clear cell renal cell carcinoma based on single-cell sequencing analysis
by: Zongyao Fan, et al.
Published: (2023-03-01)

Integrating scRNA and bulk-RNA sequencing develops a cell senescence signature for analyzing tumor heterogeneity in clear cell renal cell carcinoma
by: Qiming Gong, et al.
Published: (2023-07-01)

Cuprotosis-related signature predicts overall survival in clear cell renal cell carcinoma
by: Fan Zhang, et al.
Published: (2022-09-01)

Identification of genes of prognostic value in the ccRCC microenvironment from TCGA database
by: Bangbei Wan, et al.
Published: (2020-04-01)

Integrated genomic and proteomic analyses identify PYGL as a novel experimental therapeutic target for clear cell renal cell carcinoma
by: Mingyong Li, et al.
Published: (2024-03-01)

CD103+ Tissue Resident T-Lymphocytes Accumulate in Lung Metastases and Are Correlated with Poor Prognosis in ccRCC
by: Christine Sanders, et al.
Published: (2022-03-01)

An immune infiltration-related prognostic model of kidney renal clear cell carcinoma with two valuable markers: CAPN12 and MSC
by: Guang Xia, et al.
Published: (2023-03-01)

Expression of RSK4, CD44 and MMP-9 is upregulated and positively correlated in metastatic ccRCC
by: Jing Ma, et al.
Published: (2020-03-01)

A Prognostic Signature for Clear Cell Renal Cell Carcinoma Based on Ferroptosis-Related lncRNAs and Immune Checkpoints
by: Yunze Dong, et al.
Published: (2022-05-01)

Construction of a ferroptosis-related signature based on seven lncRNAs for prognosis and immune landscape in clear cell renal cell carcinoma
by: Shi-Yao Wei, et al.
Published: (2022-12-01)

Role of copper ionophore–induced death in immune microenvironment and clinical prognosis of ccRCC: An integrated analysis
by: Shunyao Xia, et al.
Published: (2022-10-01)

FOXM1/KIF20A axis promotes clear cell renal cell carcinoma progression via regulating EMT signaling and affects immunotherapy response
by: Kai Fang, et al.
Published: (2023-12-01)

Identification of Ligand-Receptor Pairs Associated With Tumour Characteristics in Clear Cell Renal Cell Carcinoma
by: Fahui Liu, et al.
Published: (2022-06-01)

A New Signature That Predicts Progression-Free Survival of Clear Cell Renal Cell Carcinoma with Anti-PD-1 Therapy
by: Jingwei Lin, et al.
Published: (2023-03-01)

Comprehensive analysis of a tryptophan metabolism-related model in the prognostic prediction and immune status for clear cell renal carcinoma
by: Qinfan Yao, et al.
Published: (2024-01-01)

Construction and validation of a novel ten miRNA-pair based signature for the prognosis of clear cell renal cell carcinoma
by: Yulin Wang, et al.
Published: (2022-11-01)

A pan-kidney cancer study identifies subtype specific perturbations on pathways with potential drivers in renal cell carcinoma
by: Xiaohui Zhan, et al.
Published: (2020-12-01)

Comprehensive Genomic Characterization of Tumor Microenvironment and Relevant Signature in Clear Cell Renal Cell Carcinoma
by: Chuanjie Zhang, et al.
Published: (2022-05-01)

Disturbances in Nitric Oxide Cycle and Related Molecular Pathways in Clear Cell Renal Cell Carcinoma
by: Corina Daniela Ene, et al.
Published: (2023-12-01)

The Impact of Image Acquisition Parameters and ComBat Harmonization on the Predictive Performance of Radiomics: A Renal Cell Carcinoma Model
by: Abdalla Ibrahim, et al.
Published: (2022-09-01)

Cyclin-dependent kinase 5 acts as a promising biomarker in clear cell Renal Cell Carcinoma
by: Liangsong Zhu, et al.
Published: (2019-07-01)

High GTSE1 expression promotes cell proliferation, metastasis and cisplatin resistance in ccRCC and is associated with immune infiltrates and poor prognosis
by: Pu Lei, et al.
Published: (2023-03-01)

Neutrophil extracellular traps-associated modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of clear cell renal cell carcinoma
by: Zhi-Hai Teng, et al.
Published: (2022-12-01)

Up-regulated PIF1 predicts poor clinical outcomes and correlates with low immune infiltrates in clear cell renal cell carcinoma
by: Tong Cai, et al.
Published: (2023-01-01)

Bioinformatics analysis of C3 and CXCR4 demonstrates their potential as prognostic biomarkers in clear cell renal cell carcinoma (ccRCC)
by: Jing Quan, et al.
Published: (2021-07-01)

The Clinical and Molecular Features in the VHL Renal Cancers; Close or Distant Relatives with Sporadic Clear Cell Renal Cell Carcinoma?
by: Alessandra Cinque, et al.
Published: (2022-10-01)

RETRACTED ARTICLE: Downregulation of lncRNA ZNF582-AS1 due to DNA hypermethylation promotes clear cell renal cell carcinoma growth and metastasis by regulating the N(6)-methyladenosine modification of MT-RNR1
by: Wuping Yang, et al.
Published: (2021-03-01)