Tissue-location-specific transcription programs drive tumor dependencies in colon cancer

Tissue-location-specific transcription programs drive tumor dependencies in colon cancer

Abstract Cancers of the same tissue-type but in anatomically distinct locations exhibit different molecular dependencies for tumorigenesis. Proximal and distal colon cancers exemplify such characteristics, with BRAF V600E predominantly occurring in proximal colon cancers along with increased DNA met...

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Bibliographic Details
Main Authors: Lijing Yang, Lei Tu, Shilpa Bisht, Yiqing Mao, Daniel Petkovich, Sara-Jayne Thursby, Jinxiao Liang, Nibedita Patel, Ray-Whay Chiu Yen, Tina Largent, Cynthia Zahnow, Malcolm Brock, Kathy Gabrielson, Kevan J. Salimian, Stephen B. Baylin, Hariharan Easwaran
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45605-4

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https://doi.org/10.1038/s41467-024-45605-4

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