Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome

Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome

Abstract Background Natural selection shapes cancer genomes. Previous studies used signatures of positive selection to identify genes driving malignant transformation. However, the contribution of negative selection against somatic mutations that affect essential tumor functions or specific domains...

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Bibliographic Details
Main Authors: Luis Zapata, Oriol Pich, Luis Serrano, Fyodor A. Kondrashov, Stephan Ossowski, Martin H. Schaefer
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Genome Biology
Subjects:
Tumor evolution
Negative selection
Cancer-essential genes
Neoepitopes
Cancer immunology
Online Access:http://link.springer.com/article/10.1186/s13059-018-1434-0

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http://link.springer.com/article/10.1186/s13059-018-1434-0

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