Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4
Abstract Background Evidence indicates a cross-regulation between two kinases, leucine-rich repeat kinase 2 (LRRK2) and protein kinase A (PKA). In neurons, LRRK2 negatively regulates PKA activity in spiny projecting neurons during synaptogenesis and in response to dopamine D1 receptor activation act...
প্রধান লেখক: | , , , , , , , , |
---|---|
বিন্যাস: | প্রবন্ধ |
ভাষা: | English |
প্রকাশিত: |
BMC
2018-10-01
|
মালা: | Journal of Neuroinflammation |
বিষয়গুলি: | |
অনলাইন ব্যবহার করুন: | http://link.springer.com/article/10.1186/s12974-018-1337-8 |