Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension

Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension

Introduction: Hypoxia-induced dilation of cerebral arteries orchestrated by Ca2+-permeable transient receptor potential ankyrin 1 (TRPA1) cation channels on endothelial cells is neuroprotective during ischemic stroke, but it is unknown if the channel has a similar impact during hemorrhagic stroke. T...

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Bibliographic Details
Main Authors: Michelle N. Sullivan, Pratish Thakore, Vivek Krishnan, Sushma Alphonsa, Wencheng Li, Yumei Feng Earley, Scott Earley
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
endothelium
TRPA1
stroke
hypertension
hemorrhage
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1129435/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1129435/full

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