Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes

Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes

Abstract In humans, blood Classical CD14+ monocytes contribute to host defense by secreting large amounts of pro-inflammatory cytokines. Their aberrant activity causes hyper-inflammation and life-threatening cytokine storms, while dysfunctional monocytes are associated with ‘immunoparalysis’, a stat...

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Bibliographic Details
Main Authors: Ibrahim Hawwari, Lukas Rossnagel, Nathalia Rosero, Salie Maasewerd, Matilde B Vasconcelos, Marius Jentzsch, Agnieszka Demczuk, Lino L Teichmann, Lisa Meffert, Damien Bertheloot, Lucas S Ribeiro, Sebastian Kallabis, Felix Meissner, Moshe Arditi, Asli E Atici, Magali Noval Rivas, Bernardo S Franklin
Format: Article
Language:English
Published: Springer Nature 2024-07-01
Series:EMBO Molecular Medicine
Subjects:
Hyperinflammation
Immunoparalysis
Immune Thrombocytopenia
Toll-like Receptors
Inflammasomes
Online Access:https://doi.org/10.1038/s44321-024-00093-3

Internet

https://doi.org/10.1038/s44321-024-00093-3

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