Analysis of cells of epithelial, connective tissue and immune differentiation in HPV-positive-, HPV-negative oropharyngeal carcinoma and normal oropharyngeal tissue by immunofluorescence multiplex image cytometry: a preliminary report

Analysis of cells of epithelial, connective tissue and immune differentiation in HPV-positive-, HPV-negative oropharyngeal carcinoma and normal oropharyngeal tissue by immunofluorescence multiplex image cytometry: a preliminary report

Abstract Background Epithelial, connective tissue and immune cells contribute in various ways to the pathophysiology of HPV positive (HPV+) and HPV negative (HPV-) oropharyngeal squamous cell carcinoma (OPSCC). We aimed to investigate the abundance of these cell lineages and their coexpression patte...

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Bibliographic Details
Main Authors: Aris I. Giotakis, Annette Runge, József Dudas, Rudolf Glueckert, Timo Gottfried, Volker H. Schartinger, Johanna Klarer, Avneet Randhawa, Eleonora Caimmi, Herbert Riechelmann
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Cancer
Subjects:
Image cytometry
Fluorescent antibody technique
Epithelial cells
Connective tissue
Leukocytes
Oropharyngeal neoplasms
Online Access:https://doi.org/10.1186/s12885-023-11440-x

Internet

https://doi.org/10.1186/s12885-023-11440-x

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