Decreased long-chain acylcarnitine content increases mitochondrial coupling efficiency and prevents ischemia-induced brain damage in rats

Decreased long-chain acylcarnitine content increases mitochondrial coupling efficiency and prevents ischemia-induced brain damage in rats

Long-chain acylcarnitines (LCACs) are intermediates of fatty acid oxidation and are known to exert detrimental effects on mitochondria. This study aimed to test whether lowering LCAC levels with the anti-ischemia compound 4-[ethyl(dimethyl)ammonio]butanoate (methyl-GBB) protects brain mitochondrial...

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Bibliographic Details
Main Authors: Liga Zvejniece, Baiba Svalbe, Edijs Vavers, Melita Ozola, Solveiga Grinberga, Baiba Gukalova, Eduards Sevostjanovs, Edgars Liepinsh, Maija Dambrova
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Ischemic stroke
Long-chain acylcarnitines
MCAO
ROS
Methyl-GBB
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223016013

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223016013

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