Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Age-Related Cardiac Dysfunction

Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Age-Related Cardiac Dysfunction

Summary: Cardiac myosin binding protein-C (cMyBP-C) phosphorylation prevents aging-related cardiac dysfunction. We tested this hypothesis by aging genetic mouse models of hypophosphorylated cMyBP-C, wild-type equivalent, and phosphorylated-mimetic cMyBP-C for 18 to 20 months. Phosphorylated-mimetic...

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Bibliographic Details
Main Authors: Paola C. Rosas, MD, PhD, BSPharm, Chad M. Warren, MS, Heidi A. Creed, BS, Jerome P. Trzeciakowski, PhD, R. John Solaro, PhD, Carl W. Tong, MD, PhD
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X1930186X

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http://www.sciencedirect.com/science/article/pii/S2452302X1930186X

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