Investigation of tryptophan to kynurenine degradation in response to interferon-γ in melanoma cell lines

Investigation of tryptophan to kynurenine degradation in response to interferon-γ in melanoma cell lines

Background and aim: Melanoma is a fatal form of skin cancer that carries a grave prognosis if the cancer cells spread and form metastases. The Kynurenine (Kyn) pathway is activated by the enzyme indoleamine 2,3-dioxygenase 1 (IDO-1) and has been shown to have a role in tumour progression. We have pr...

Full description

Bibliographic Details
Main Authors: Helena Tassidis, Skaidre Jankovskaja, Kassem Awad, Lars Ohlsson, Anette Gjörloff Wingren, Anna Gustafsson
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
IDO-1
Interferon-γ
Kynurenine
Melanocytes
melanoma
Programmed death ligand 1
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580823001930

Internet

http://www.sciencedirect.com/science/article/pii/S2405580823001930

Similar Items