436 Immunotherapy Sensitization via Tumor Acidosis Mitigation by Esomeprazole Monitored with MRI

436 Immunotherapy Sensitization via Tumor Acidosis Mitigation by Esomeprazole Monitored with MRI

OBJECTIVES/GOALS: Acidity and the lactate-to-pyruvate ratio correlate with immunotherapy resistance. AcidoCEST MRI and hyperpolarized magnetic resonance spectroscopy (HP-MRS) measure extracellular pH and lactate-to-pyruvate ratio. We will establish a baseline for these biomarkers then observe change...

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Bibliographic Details
Main Authors: Grace Abigail Murley, Shivanand Pudakalakatti, William Padron, Muxin Wang, Ryan Armijo, Jorge Delacerda, Abishai Dominic, Renee Chin, William Schuler, Kunal Rai, Marty Pagel, Pratip Bhattacharya
Format: Article
Language:English
Published: Cambridge University Press 2024-04-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866124003765/type/journal_article

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https://www.cambridge.org/core/product/identifier/S2059866124003765/type/journal_article

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