A New Potent Inhibitor against α-Glucosidase Based on an In Vitro Enzymatic Synthesis Approach

A New Potent Inhibitor against α-Glucosidase Based on an In Vitro Enzymatic Synthesis Approach

Inhibiting the activity of intestinal α-glucosidase is considered an effective approach for treating type II diabetes mellitus (T2DM). In this study, we employed an in vitro enzymatic synthesis approach to synthesize four derivatives of natural products (NPs) for the discovery of therapeutic drugs f...

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Bibliographic Details
Main Authors: Huanyu Zhang, Xiance Che, Hongyan Jing, Yaowu Su, Wenqi Yang, Rubing Wang, Guoqi Zhang, Jie Meng, Wei Yuan, Juan Wang, Wenyuan Gao
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Molecules
Subjects:
in vitro enzymatic synthesis
type II diabetes mellitus
network pharmacology
molecular docking
molecular dynamics simulation
site-directed mutagenesis
Online Access:https://www.mdpi.com/1420-3049/29/4/878

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https://www.mdpi.com/1420-3049/29/4/878

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