Cell confinement reveals a branched-actin independent circuit for neutrophil polarity.

Migratory cells use distinct motility modes to navigate different microenvironments, but it is unclear whether these modes rely on the same core set of polarity components. To investigate this, we disrupted actin-related protein 2/3 (Arp2/3) and the WASP-family verprolin homologous protein (WAVE) co...

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Bibliographic Details
Main Authors: Brian R Graziano, Jason P Town, Ewa Sitarska, Tamas L Nagy, Miha Fošnarič, Samo Penič, Aleš Iglič, Veronika Kralj-Iglič, Nir S Gov, Alba Diz-Muñoz, Orion D Weiner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-10-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000457