C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death

C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death

Abstract Lysosomes are degradation and signaling centers within the cell, and their dysfunction impairs a wide variety of cellular processes. To understand the cellular effect of lysosome damage, we screened natural small-molecule compounds that induce lysosomal abnormality using Caenorhabditis eleg...

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Bibliographic Details
Main Authors: Yang Li, Yu Zhang, Qiwen Gan, Meng Xu, Xiao Ding, Guihua Tang, Jingjing Liang, Kai Liu, Xuezhao Liu, Xin Wang, Lingli Guo, Zhiyang Gao, Xiaojiang Hao, Chonglin Yang
Format: Article
Language:English
Published: Oxford University Press 2018-04-01
Series:Protein & Cell
Subjects:
lysosome
alkaloids
lysosomal cell death
STAT3
Caenorhabditis elegans
Online Access:http://link.springer.com/article/10.1007/s13238-018-0520-0

Internet

http://link.springer.com/article/10.1007/s13238-018-0520-0

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